In this section we provide relevant literature on different cardiovascular topics. Click on the links to access to each paper.

• Potente M, Gerhardt H, Carmeliet P. 
Basic and therapeutic aspects of angiogenesis. Cell. 2011 Sep 16;146(6):873-87.

• Martinez MC, Andriantsitohaina R. 
Microparticles in angiogenesis: therapeutic potential. Circ Res. 2011 Jun 24;109(1):110-9.

• Carmeliet P, Jain RK. 
Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011 May 19;473(7347):298-307.

• Kiefer F, Siekmann AF.
The role of chemokines and their receptors in angiogenesis. Cell Mol Life Sci. 2011 Sep;68(17):2811-30.

• Wykrzykowska JJ, Henry TD, Lesser JR, Schwartz RS. 
Imaging myocardial angiogenesis. Nat Rev Cardiol. 2009 Oct;6(10):648-58.

• Ahn A, Frishman WH, Gutwein A, Passeri J, Nelson M. 
Therapeutic angiogenesis: a new treatment approach for ischemic heart disease--part I. Cardiol Rev. 2008 Jul-Aug;16(4):163-71.

• Ahn A, Frishman WH, Gutwein A, Passeri J, Nelson M. 
Therapeutic angiogenesis: a new treatment approach for ischemic heart disease--Part II. Cardiol Rev. 2008 Sep-Oct;16(5):219-29.

• Molin D, Post MJ. 
Therapeutic angiogenesis in the heart: protect and serve. Curr Opin Pharmacol. 2007 Apr;7(2):158-63.

• Shiojima I, Walsh K.
Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway. Genes Dev. 2006 Dec 15;20(24):3347-65.

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Atherosclerosis

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Atrial fibrillation

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Burden of cardiovascular diseases

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Biomarkers

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Cardiomyocytes

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Baum J, Duffy HS.
Fibroblasts and myofibroblasts: what are we talking about? J Cardiovasc Pharmacol. 2011 Apr;57(4):376-9.


Vasquez C, Benamer N, Morley GE.
The cardiac fibroblast: functional and electrophysiological considerations in healthy and diseased hearts. J Cardiovasc Pharmacol. 2011 Apr;57(4):380-8.


Yue L, Xie J, Nattel S. 
Molecular determinants of cardiac fibroblast electrical function and therapeutic implications for atrial fibrillation. Cardiovasc Res. 2011 Mar 1;89(4):744-53.


Krenning G, Zeisberg EM, Kalluri R.
The origin of fibroblasts and mechanism of cardiac fibrosis. J Cell Physiol. 2010 Nov;225(3):631-7.


Leask A.
Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation. Circ Res. 2010 Jun 11;106(11):1675-80.


Kakkar R, Lee RT. 
Intramyocardial fibroblast myocyte communication. Circ Res. 2010 Jan 8;106(1):47-57.


Souders CA, Bowers SL, Baudino TA.
Cardiac fibroblast: the renaissance cell. Circ Res. 2009 Dec 4;105(12):1164-76. 


Manso AM, Kang SM, Ross RS.
Integrins, focal adhesions, and cardiac fibroblasts. J Investig Med. 2009 Dec;57(8):856-60.


van den Borne SW, Diez J, Blankesteijn WM, Verjans J, Hofstra L, Narula J.
Myocardial remodeling after infarction: the role of myofibroblasts. Nat Rev Cardiol. 2010 Jan;7(1):30-7.


Snider P, Standley KN, Wang J, Azhar M, Doetschman T, Conway SJ.
Origin of cardiac fibroblasts and the role of periostin. Circ Res. 2009 Nov 6;105(10):934-47. 


Rohr S.
Myofibroblasts in diseased hearts: new players in cardiac arrhythmias? Heart Rhythm. 2009 Jun;6(6):848-56.


Porter KE, Turner NA.
Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther. 2009 Aug;123(2):255-78.


Camelliti P, Green CR, Kohl P.
Structural and functional coupling of cardiac myocytes and fibroblasts. Adv Cardiol. 2006;42:132-49.


Baudino TA, Carver W, Giles W, Borg TK.
Cardiac fibroblasts: friend or foe? Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1015-26. 


Brown RD, Ambler SK, Mitchell MD, Long CS.
The cardiac fibroblast: therapeutic target in myocardial remodeling and failure. Annu Rev Pharmacol Toxicol. 2005;45:657-87.


Manabe I, Shindo T, Nagai R.
Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res. 2002 Dec 13;91(12):1103-13. 

Diabetes and heart disease >

van Heerebeek L, Somsen A, Paulus WJ.

The failing diabetic heart: focus on diastolic left ventricular dysfunction. Curr Diab Rep. 2009 Feb;9(1):79-86.

Extracellular matrix and heart  >

Creemers EE, Pinto YM. 

Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart. Cardiovasc Res. 2011 Feb 1;89(2):265-72

Jourdan-Lesaux C, Zhang J, Lindsey ML.

Extracellular matrix roles during cardiac repair. Life Sci. 2010 Sep 25;87(13-14):391-400.

Espira L, Czubryt MP.

Emerging concepts in cardiac matrix biology. Can J Physiol Pharmacol. 2009 Dec;87(12):996-1008.

Pellman J, Lyon RC, Sheikh F.

Extracellular matrix remodeling in atrial fibrosis: mechanisms and implications in atrial fibrillation. J Mol Cell Cardiol. 2010 Mar;48(3):461-7.

Bowers SL, Banerjee I, Baudino TA.

The extracellular matrix: at the center of it all. J Mol Cell Cardiol. 2010 Mar;48(3):474-82

Fomovsky GM, Thomopoulos S, Holmes JW.

Contribution of extracellular matrix to the mechanical properties of the heart. J Mol Cell Cardiol. 2010 Mar;48(3):490-6. 

Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG.

The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol. 2010 Mar;48(3):504-11.

Zamilpa R, Lindsey ML.

Extracellular matrix turnover and signaling during cardiac remodeling following MI: causes and consequences. J Mol Cell Cardiol. 2010 Mar;48(3):558-63.

Zannad F, Rossignol P, Iraqi W.

Extracellular matrix fibrotic markers in heart failure. Heart Fail Rev. 2010 Jul;15(4):319-29.

Akhyari P, Kamiya H, Haverich A, Karck M, Lichtenberg A.

Myocardial tissue engineering: the extracellular matrix. Eur J Cardiothorac Surg. 2008 Aug;34(2):229-41.

Samuel CS, Lekgabe ED, Mookerjee I.

The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease. Adv Exp Med Biol. 2007;612:88-103. 

Spinale FG.

Myocardial matrix remodeling and the matrix metalloproteinases: influence on cardiac form and function. Physiol Rev. 2007 Oct;87(4):1285-342.

Berk BC, Fujiwara K, Lehoux S.

ECM remodeling in hypertensive heart disease. J Clin Invest. 2007 Mar;117(3):568-75.

Banerjee I, Yekkala K, Borg TK, Baudino TA.

Dynamic interactions between myocytes, fibroblasts, and extracellular matrix. Ann N Y Acad Sci. 2006 Oct;1080:76-84. 

Gupta V, Grande-Allen KJ.

Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells. Cardiovasc Res. 2006 Dec 1;72(3):375-83. 

Coghlan HC, Coghlan AR, Buckberg GD, Cox JL.

'The electrical spiral of the heart': its role in the helical continuum. The hypothesis of the anisotropic conducting matrix. Eur J Cardiothorac Surg. 2006 Apr;29 Suppl 1:S178-87.

Miner EC, Miller WL.

A look between the cardiomyocytes: the extracellular matrix in heart failure. Mayo Clin Proc. 2006 Jan;81(1):71-6.

Deschamps AM, Spinale FG.

Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation. Cardiovasc Res. 2006 Feb 15;69(3):666-76.

Manso AM, Elsherif L, Kang SM, Ross RS.

Integrins, membrane-type matrix metalloproteinases and ADAMs: potential implications for cardiac remodeling. Cardiovasc Res. 2006 Feb 15;69(3):574-84. 

Brown L.

Cardiac extracellular matrix: a dynamic entity. Am J Physiol Heart Circ Physiol. 2005 Sep;289(3):H973-4.

Kassiri Z, Khokha R.

Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors. Thromb Haemost. 2005 Feb;93(2):212-9.

Schellings MW, Pinto YM, Heymans S.

Matricellular proteins in the heart: possible role during stress and remodeling. Cardiovasc Res. 2004 Oct 1;64(1):24-31. 

Rosenkranz S.

TGF-beta1 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 2004 Aug 15;63(3):423-32. 

Janicki JS, Brower GL, Gardner JD, Chancey AL, Stewart JA Jr.

The dynamic interaction between matrix metalloproteinase activity and adverse myocardial remodeling. Heart Fail Rev. 2004 Jan;9(1):33-42. 

Jugdutt BI.

Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough? Circulation. 2003 Sep 16;108(11):1395-403. 

Lindsey ML, Mann DL, Entman ML, Spinale FG.

Extracellular matrix remodeling following myocardial injury. Ann Med. 2003;35(5):316-26.

MicroRNAs and cardiovascular system  >